Extended Data Fig. 9: Structural analysis and sequence alignment of SLCO6C1.

a, Side view (left) and central slice view (right) of the electron density map of SLCO6C1 and the adjacent components. The map was generated in ChimeraX. b, SLCO6C1 is captured in an outward-facing conformation. The structure is shown in cylindrical helices cartoon mode and coloured by domain. Right, the N and C domains of SLCO6C1 each contain six transmembrane helices and are pseudo-symmetric, with an r.m.s.d. of ~6 Å when superimposed. c, Sequence alignment among mouse SLCO6C1, rat SLCO6C1 and human SLCO6A1. The glycosylation site (red triangle) and the residues that may be involved in interactions with CATSPERε (yellow triangles) are conserved among species. The uniport IDs for the aligned sequences are: mSLCO6C1: Q3V161; rSLCO6C1: G3V7R7; and hSLCO6A1: Q86UG4.