Extended Data Fig. 5: Characterization of molecular identity and signal-receptor repertoire of neural tube organizers. | Nature

Extended Data Fig. 5: Characterization of molecular identity and signal-receptor repertoire of neural tube organizers.

From: Molecular architecture of the developing mouse brain

Extended Data Fig. 5

a, Cell types sorted on the basis of the average Z score of morphogens genes grouped in categories on the basis of gene family and neurulation literature. Hedgehog, Shh and Ptch1; R-spondins, Rspo1, Rspo2, Rspo3 and Rspo4; Wnts, Wnt1, Wnt3a, Wnt5a and Wnt8b; neuregulins, Nrg1, Nrg3 and Fgf7; Fgfs, Fgf8, Fgf15, Fgf17 and Fgf18; Bmps, Bmp6, Bmp7 and Gdf7. Cell types displayed in red were localized and analysed in Fig. 2 and in the panels below. b, Summary of the plots in a showing the maximum average z score achieved. c, Beeswarm plots showing the expression of a selection of transcription factors that were found to be enriched in the different organizer cell populations. d, Beeswarm plots showing the gene expression of enriched receptors and ligands with a distribution in relation to organizers that, to our knowledge, had not previously been described. Genes in c, d were selected for HybISS profiling (Fig. 4).

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