Extended Data Fig. 6: Decomposition of polyclonal samples. | Nature

Extended Data Fig. 6: Decomposition of polyclonal samples.

From: Extensive phylogenies of human development inferred from somatic mutations

Extended Data Fig. 6

Phylogenetic trees with unit branch lengths for four polyclonal samples of the epidermis from PD28690, showing the contribution (blue) of early embryonic progenitors in the phylogeny to the sample. These samples were not used for the reconstruction of the phylogeny because of their lack of a dominant clone, but can still be decomposed into the contributing embryonic lineages that give rise to these polyclonal aggregates. For example, ‘SKN2_D2’, while somatically polyclonal, seems to be derived from a single early lineage.

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