Extended Data Fig. 2: Model of early embryogenesis and ABC.
From: Extensive phylogenies of human development inferred from somatic mutations
a, Heat maps showing the results of estimates of the early embryonic bottleneck obtained through approximate Bayesian computation, with and without cell death rate as a parameter (Methods). The darkness of the colour indicates the frequency of the observed bottleneck in the accepted simulations. b, Estimates of the mutation rate per cell per division before and after zygotic genome activation (ZGA); the dot indicates the mean of the 20,000 accepted simulations and the line spans the 95% confidence interval.
