Extended Data Fig. 4: Embryonic patch size in the colon.
From: Extensive phylogenies of human development inferred from somatic mutations
a, Kernel smoothed 2D histogram of the linear distance (in number of crypts) and the number of shared SNVs between any two crypts from the same biopsy. The red line is shown at a shared SNV burden of 15, above which crypts were taken to be from the same embryonic patch. b, Histogram of the number of SNVs shared between all pairs of crypts showing a bimodal distribution on either side of an SNV burden of 15 (red line). c, Density plot of the prior distribution of the embryonic patch size radius. d, Plot of the radius versus the Euclidean distance in summary statistics between the simulations and our observed data. The red dots indicate those within the 5% closest simulations and are accepted. e, Density plot of the prior distribution (dashed line), the posterior distribution from the rejection method (black line) and the posterior distribution from the neural network regression (red line) of the embryonic patch size radius. f, A QQ-plot of the residuals of the neural network regression.
