Extended Data Fig. 1: Antibody responses to BNT162b2 vaccination.
From: Systems vaccinology of the BNT162b2 mRNA vaccine in humans
a, Schematic of the study design and the number of participants used in various assays. b, c, Binding (b) and neutralizing (c) antibody responses to BNT162b2 vaccination in female and male participants (n = 56). d, e, Correlation between binding antibody and neutralizing antibody titres (d) and neutralizing antibody responses and age (e). f, Neutralizing antibody response to B.1.351 variant of concern in female and male participants (n = 30). g, Correlation between age and cross-neutralization index, defined as the ratio of neutralizing antibody response to B.1.351 versus WA1 strains. Each dot represents an individual in all plots. Blue and red colour denote female and male participants, respectively. Boxes show median and 25th–75th percentiles, and whiskers show the range in all box plots. All correlations are two-sided Spearman’s correlations. The error bands represent 95% confidence limits. The statistical difference between time points is calculated using two-sided Wilcoxon matched-pairs signed-rank test and the statistical differences between groups were calculated using two-sided Mann–Whitney rank-sum test. ***P < 0.001, **** P < 0.0001.
