Extended Data Fig. 1: Antibody neutralization and binding data.

a, Neutralization of authentic SARS-CoV-2 (SARS-CoV-2-Nluc) by 14 antibodies. Shown are representative live virus neutralization plots, measured with entry into Vero E6 cells. Symbols are means ± s.d. of technical triplicates. Dashed lines indicate IC₅₀ and IC₉₀ values. All antibodies were measured at each concentration point in the series, with hidden points due to overplotting reflecting overlap at the upper and lower neutralization limits. b, Correlation in antibody neutralization IC₅₀ as determined in spike-pseudotyped VSV particles (n = 3 to 8) versus authentic SARS-CoV-2 (n = 3). c, Representative SPR sensorgrams of Fab fragments of the six newly described antibodies binding to the SARS-CoV-2 RBD (Fig.1a gives average values for n = 2–4 measurements). White and grey stripes indicate association and dissociation phases, respectively. Data shown in blue and fit to binding model shown in dashed gray line. Binding affinities for previously described antibodies shown in Fig. 1a are consistent with measurements from Piccoli et al. (S304, S309, S2X35, S2H13, S2H14)¹⁵ and Tortorici et al. (S2E12)⁸. d, Identifiers and spike genotypes of SARS-CoV-2 variants tested in neutralization assays in Figs. 2d, 3b.