Extended Data Table 1 Characteristics of the antibodies described in this study

From: SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

  1. VH and VL percent identity refers to V gene segment identity compared to germline (as per the International Immunogenetics Information System (http://www.imgt.org/)). HCDR3 length was determined using IMGT. SARS-CoV-2 neutralization potency (authentic virus [n = 3] and spike-pseudotyped VSV particles [n = 3 to 8] on Vero E6 cells), Fab:RBD binding affinities measured by SPR [n = 2 to 4]. Some binding affinities for previously described antibodies were measured in Piccoli et al. 15 (S304, S309, S2X35, S2H13, S2H14)*, Tortorici et al. 8 (S2E12)† and Cathcart et al. 22 (VIR-7831, derived from S309)‡. Values in brackets are minimum and maximum determined values. §Spike binding data are “apparent affinity” or KD,app, because RBD conformational dynamics affect the kinetics. S2H97 Fab binding to spike doesn't fit well to 1:1 binding, presumably because of changing epitope accessibility. ||Biphasic kinetics; Fit result is for fast phase. ND, not determined.
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