Extended Data Fig. 3: Circadian and ultradian rhythms in SPW-R rate.
From: A metabolic function of the hippocampal sharp wave-ripple
a, Histogram of SPW-R rate for data from eight rats and sessions (n = 1,568.5 recording hours from 8 rats; mean = 196 ± 84 h). b, Modulation of the SPW-R rate across the circadian timescale. Grey lines are individual rats, black line is the population average. c, Example auto-correlograms (±12 h) of SPW-R rate for three rats. d, Average power spectral density plot (n = 8 rats) of ripple rate. Note two peaks at about 24 h and about 4 h. e, Cross-correlograms of detected SPW-Rs and CA1 population firing rates at two temporal scales. Left, 100-ms bins; right, 60-s median filter. At slow temporal scales (>250 ms), CA1 SPW-Rs are associated with an overall decrease in CA1 firing rates.
