Extended Data Table 1 Human clinical studies
From: APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans
- a, Univariate and multivariate Cox regression analyses of the ICARAS study (nc-APRIL). First tertile includes patients with nc-APRIL levels lower than 4.22 ng ml−1, second tertile patients with nc-APRIL levels between 4.23 and 6.47 ng ml−1, and the third tertile patients with nc-APRIL levels above 6.47 ng ml−1. Adjusted for age, sex, body mass index, smoking, hypertension, LDL cholesterol levels, triglyceride levels, statin treatment, glycohaemoglobin A1 level, diabetes mellitus, history of myocardial infarction, history of peripheral artery disease, history of stroke, and serum creatinine, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and high-sensitivity C-reactive protein. The third tertile serves as the reference category (n = 785). b, Univariate and multivariate Cox regression analyses of the ICARAS study (c-APRIL). First tertile includes patients with APRIL levels lower than 1.67 ng ml−1, second tertile patients with APRIL levels between 1.67 and 2.54 ng ml−1, and the third tertile patients with APRIL levels above 2.54 ng ml−1. Adjusted for age, sex, body mass index, smoking, hypertension, LDL cholesterol levels, triglyceride levels, statin treatment, glycohaemoglobin A1 level, diabetes mellitus, history of myocardial infarction, history of peripheral artery disease, history of stroke, and serum creatinine, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and high-sensitivity C-reactive protein. The third tertile serves as the reference category (n = 730). c, Multivariate Cox regression analyses for cardiovascular mortality in the LURIC study (nc-APRIL). Adjusted for age (years), sex (male/female), C-reactive protein (mg dl−1), triglycerides (mg dl−1), total cholesterol levels (mg dl−1), history of myocardial infarction (binary), history of stroke (binary), peripheral arterial disease (binary), body mass index (kg/m2), hypertension (binary), diabetes mellitus (binary), serum creatinine (mg dl−1), haemoglobin 1AC (per cent) (n = 1,514). d, Multivariate Cox regression analyses for the FAST-MI study. Circulating levels of nc-APRIL in patients at admission for acute myocardial infarction are associated with cardiovascular outcomes at follow-up. The probability of death during 2 years of follow-up as a function of baseline circulating plasma nc-APRIL levels (n = 974). Results are expressed as hazard ratios (HR) with 95% CI.
