Extended Data Fig. 1: Individual datatype classification of meningiomas.

a, Violin plots showing the distribution of the normalized mutual information (MI) for each pairwise comparison of datatype. Median is shown as white dot. The number of total genes and number of genes with statistically significant (FDR < 5%) MI values are shown. Below this is a heatmap showing the consensus clustering of genes where MI was significant for at least one datatype pair. Rows represent a gene for which data exists from all data types. b,d,f, Unsupervised consensus hierarchical clustering of (b), 5,000 genes that show that highest median absolute deviation across expression values, (d), 10,000 CpG sites that show that highest median absolute deviation across β-values, (f), 1,000 genes that show that highest median absolute deviation across copy number ratios. Heatmap of consensus matrices with K = 6 groups (b,d,f) are displayed. Overall, six groups were most stable across all platforms. c,e,g, Kaplan Meier-plot displaying recurrence-free survival (RFS) distributions of unsupervised cluster assignments by (c) mRNA data, (e) DNA methylation data, (g) copy number data. The associations with outcomes are unique for the 6 cluster groups obtained on individual platform analyses. h, Average silhouette widths for unsupervised consensus hierarchical clustering from K = 2 to K = 10. The silhouette score is a measure of stability of number of groups. Higher scores indicate greater stability and robustness. Average silhouette width is highest at K = 4 subgroups. i, Alluvial plot demonstrating associations between WHO grade and integrative molecular groups defined in this study. j-l, Kaplan Meier-plot displaying recurrence-free survival (RFS) distributions of patients stratified and colored by molecular group assignments for WHO grade 1 tumors (j), WHO grade 2 tumors (k), and WHO grade 3 tumors (l).