Extended Data Fig. 3: Most mutations are clonal in meningioma.
From: A clinically applicable integrative molecular classification of meningiomas
a, Lollipop plots showing the distribution of NF2 mutations by genomic regions within each molecular group. b, Mutational burden (nonsynonymous mutations per megabase) of meningiomas stratified by molecular groups in comparison to other TCGA solid cancers. Every dot represents a sample and horizontal lines are median number of mutations in each cancer type. Mutational burden in each cancer is ordered by percentile rank. Cancer types are ordered on the horizontal axis based on their median numbers of somatic mutations. Mutational burden of MG4 tumors is statistically higher than tumours in MG1-3 (P = 1.6 × 10−3, Kruskal Wallis test). c, Distribution of the number of mutations that are considered clonal per each patient sample (column). A total of 26% of tumors exhibited only clonal point mutations. In the median tumor, 75% of single nucleotide variants were clonal. d, Cancer cell fraction of all variants in each patient sample (columns) ordered as in (c). Variants are colored according to the classification in the legend. e, Cancer cell fraction of recurrent oncogenic driver mutations (columns). Variants are colored according to the classification in the legend.
