Extended Data Fig. 2
From: Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia
Effects of VCP171 and MIPS521 on spontaneous excitatory synaptic activity. a, Examples of spontaneous excitatory postsynaptic potentials (sEPSCs) recorded from neurons of the superficial laminae of the spinal dorsal horn of nerve-injured rats. b, sEPSC frequency and amplitude were reduced following superfusion of VCP171 or MIPS521, which is reversed by the antagonist, DPCPX (n = 8 per group). Significance compared to baseline was determined using a two-tailed paired t test, *P < 0.05, **P < 0.01.
