Extended Data Fig. 2: Cryo-EM reconstructions.
a, Cryo-EM maps for tau filaments from six cases of PSP. For each map, a sum of the reconstructed density for several XY-slices is shown, corresponding to approximately 4.7 Å. The disease cases are referenced at the bottom of each image, the filament types at the top left and the percentages of a given filament type among the tau filaments in the dataset at the top right. Scale bar 5 nm. The same scale applies to all panels, except d–g. b–h, As in a, but a case of GGT-I and a case of GGT-II (b); a case diagnosed as PSP-F, but that contains filaments with the PGT fold (c); two cases of AGD (d); scale bar 5nm, the same scale applies to panels d–g; entorhinal cortex of PSP-RS case 3 (e); a case of ARTAG (f); three cases with mutations +16 or +3 in intron 10 of MAPT (g); a case of FBD and a case of FDD (h). Panels d–f contain blank squares to indicate the absence of AGD type I filaments in some cases. The inset with dashed lines shows 2D class average images of tau filaments from a case of GGT-III without apparent twist.
