Extended Data Fig. 5: MEK inhibitor prevents PanIN formation from TERT-High cells expressing mutant Kras. | Nature

Extended Data Fig. 5: MEK inhibitor prevents PanIN formation from TERT-High cells expressing mutant Kras.

From: Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis

Extended Data Fig. 5

a, Schema of cerulein-induced pancreatitis with MEKi treatment (Trametinib). b, c, H&E (b) and Tomato (c) staining of TertCreER; Kras mice one month after cerulein induced pancreatitis with (Trametinib) and without (Vehicle) MEKi treatment. d, Quantification of Tomato-positive cells per clone with (n=4 mice) and without (n=3 mice) MEK inhibition (mean ± SD). Scale bars, 100µm.

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