Extended Data Fig. 5: Sequence alignment of glycoprotein hormones and related receptors.
From: Structures of full-length glycoprotein hormone receptor signalling complexes
a, Sequence alignment of human FSHR, LHR and TSHR in the region of the hormone-binding domain. Residues only interact with CGβ (light sea green), CGα (pink), and both CGα and CGβ subunits (light blue) are highlighted. Residues that determine LHCGR specificity were labeled with asterisks. b, Sequence alignment of human CG, LH, TSH and FSH β-subunit. CGβ residues interacted with LHCGR are highlighted in light sea green. c, The α-subunit sequence of glycoprotein hormones. CGα residues interacted with LHCGR are highlighted in pink.
