Fig. 1: DC-SIGN, L-SIGN and SIGLEC1 function as attachment receptors for SARS-CoV-2 infection.
From: Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies
a, VSV-SARS-CoV-2 infection of HEK 293T cells transfected to express ACE2 or a panel of selected lectins or candidate receptors (n = 4 biologically independent replicates). RLU, relative luminescence units. b, Stable cell lines were infected with SARS-CoV-2-Nluc and luciferase levels were quantified at 24 h (n = 6). c, Inhibition of SARS-CoV-2-Nluc infection with anti-SIGLEC1 monoclonal antibody (clone 7-239) (n = 3). d, Indicated cell lines were transduced to express lectins or ACE2 and infected with VSV-SARS-CoV-2 (n = 8). e, Effect of ACE2 siRNA transfection on infection with VSV-SARS-CoV-2 (n = 8).
