Extended Data Fig. 2: Developmental characterization of embryonic E13 MGE cells surveyed using scRNA-seq, scATAC-seq, and multiomic methods.
From: Genetic and epigenetic coordination of cortical interneuron development
a, Analysis of Dlx6a−, Dlx6a+ and multiome scRNA-seq datasets collected from E13 MGE in Dlx6a−Cre;Ai9 mice and multiome dataset in E13 MGE wild type mice. b, Analysis of Dlx6a−, Dlx6a+ and multiome scATAC-seq datasets collected from E13 MGE in Dlx6a−Cre;Ai9 mice and multiome dataset in E13 MGE wild type mice. i, Dlx6+/− FAC-sorted and multiome cells. ii, Unbiased cluster annotation. iii, Dlx6+ and Dlx6− annotation. iv, Cell cycling phase annotation. v, Pseudotime annotation. vi, Mitotic and postmitotic cell annotation. In ii-vi, Annotations are performed on scRNA-seq datasets and transferred to scATAC-seq datasets through the multiome dataset. scRNA- and scATAC-seq low dimensional representation reflects UMAP embedding. vii, Average gene expression and promoter accessibility for unbiased clusters.
