Extended Data Fig. 9: Conformational change of GluK2-Neto2 complex upon desensitization.

a, Superimposition of agonist bound LBDs of 4BDM (grey) and GluK2-1×Neto2^des (red). b, Superimposition of ATD-CUB1-LBD interactions between GluK2-1×Neto2^asymLBD (grey) and GluK2-1×Neto2^des (red, orange and blue). c, Organization of the D1 lobe of the GluK2-1×Neto2^des (red and blue) and desensitized GluK2 alone (grey). COMs of the lobes are depicted as black dots. Distances and angles are indicated. d, The LBD rearrangement between GluK2-1×Neto2 and GluK2-1×Neto2^des upon desensitization. e, Displacement of LBD at B-position of GluK2-1×Neto2^des complex (red, blue and orange) compared with desensitized GluK2 (5KUF, grey).