Extended Data Fig. 9: Dopamine unilateral inhibition during fan cell recording.

(a) Performance of mice during unilateral dopamine inhibition. (Left) Performance of mice in trials 121-160 as in Fig. 4a, but assessed with discriminability index (D-prime) (p=5.1e-4, ANOVA;p = 9.6e-3 or better, post-hoc Tukey test; n = 8 mice). (Middle) Learning curves during control (left) and unilateral dopamine inhibition (right) sessions. In these plots, the data shown in Fig. 4a were plotted for percent correct trials in each odour trial type as a function of trial number for each odour type. Plot using 2-trial moving window is also shown for control sessions. (Right) Performance of mice in the last 10 trials (p=6.5e-6, ANOVA;p =  0.046 or better, post-hoc Tukey test; n = 10 mice). In the unilateral dopamine inhibition experiments, each mouse (n = 8) had 10 – 16 inhibition sessions. Of them, percentage of correct sessions (i.e. #correct sessions/(#correct sessions + #error sessions)) were 46.6%, 55.6%, 43.3%, 50.0%, 54.7%, 53.6%, 53.6%, and 42.8%. (b). We performed control experiments using DAT-Cre mice injected with AAV-DIO-ChR2 and AAV-flex-GFP for unilateral opt-tagging and laser control (n = 4 mice). The GFP control experiment showed same result as no-laser control in Fig. 4a (p=0.035, ANOVA;p =  0.044 or better, post-hoc Tukey test; n = 4 GFP control mice; n = 8 Jaws inhibition mice).