Extended Data Fig. 7: Effects of in vivo optogenetic low frequency stimulation to induce LTD at MS to dCA2 synapses on sociability, social memory and object memory.
From: 5-HT modulation of a medial septal circuit tunes social memory stability
a, b, Duration in chambers with fm or nm (left) and discrimination scores (right), LTD stimulation (1 Hz for 10 min) was performed prior to sociability test, (a: t13 = 2.898, P = 0.0125; off: n = 15, 1 Hz: n = 14. b: t9 = 0.9806, P = 0.3524; n = 10). c, d, Duration in chamber with no or nm, left and discrimination scores (right) in ChR2 and eYFP mice, LTD stimulation (1 Hz for 5 min) was performed after sociability test (c: t9 = 0.3201, P = 0.7563; n = 10, d: t9 = 0.6328, P = 0.5426; n = 10). e, Duration with fo or no (left) and discrimination scores (right) (t9 = 0.09968, P = 0.9228; n = 10) in ChR2 mice. f, g, Duration in chamber with no or nm, left and discrimination scores (right) in ChR2 and eYFP mice (f: t13 = 0.7717, P = 0.4540; n = 14, g: t9 = 1.208, P = 0.2577; n = 10). h, Duration with fo or no (left) and discrimination scores (right) (t13 = 0.6186, P = 0.5469; n = 14) in ChR2 mice. Two-tailed paired Student’s t-test was performed on all data. N.S. = not significant, *P < 0.05, **P < 0.01, ***P < 0.001. Error bars denote s.e.m.
