Extended Data Fig. 3: Optogenetic MS cell body and chemogenetic terminal inhibition do not affect sociability and object memory.
From: 5-HT modulation of a medial septal circuit tunes social memory stability
a, Schematic of experimental set-up (left) and representative image of MS injection site showing NpHR expression (right). n = 10. Scale bar, 500 μm. b, Duration in chamber with no or nm (left) and discrimination scores (right) (t18 = 0.9531, P = 0.3532; n = 10). c, Duration in chamber with fo or no (left) and discrimination scores (right) (t18 = 0.1348, P = 0.8943; n = 10). d, Schematic of experimental set-up (left) and representative images of MS injection sites showing hM4Di expression and cannula implant sites (right). n = 13. Scale bar, 500 μm. e, Duration in chamber with no or nm (left) and discrimination scores (right) (t26 = 0.2453, P = 0.8081; mCh: n = 15, hM4Di: n = 13). f, Duration in chamber with fo or no (left) and discrimination scores (right) (t22 = 0.6383, P = 0.5298; n = 12). All data were assessed by two-tailed unpaired Student’s t-test. N.S. = not significant, *P < 0.05, ***P < 0.001. Error bars denote s.e.m.
