Extended Data Fig. 12: Analysis of telomere lengths.
From: Convergent somatic mutations in metabolism genes in chronic liver disease
a, Scatter plot showing the distribution of telomere lengths for samples grouped by disease status, and ranked from lowest to highest age within each disease category. b, Posterior distributions of the effect size of clone size (per log10(μm2)), age (per decade of life) and disease state (NAFLD and ARLD versus normal) on telomere lengths. Density plots are shown from the MCMC sampler, coloured by decile. Posterior ‘p values’ are calculated from the posterior samples of the MCMC chain and are two-sided and not corrected for multiple hypothesis testing. c, Telomere lengths layered onto two representative phylogenetic trees from patients with ARLD. Branches are coloured on a yellow-to-blue scale according to telomere lengths of the sample with the highest VAF assigned to that branch. The internal nodes are estimated using maximum likelihood and colours are interpolated along each branch.
