Extended Data Fig. 1: Effects of 144 antibiotics on 40 human gut commensals.
From: Unravelling the collateral damage of antibiotics on gut bacteria
Heat map according to sensitivity or resistance of each strain to the respective antibiotic at a concentration of 20 µM. Antibiotics are grouped according to drug classes and species are clustered according to their responses across the 144 antibiotics tested. Data is replotted from2. Of note, Akkermansia muciniphila, a species associated with protection against different diseases and dysbiotic states62, and even positive responses to immunotherapy63, is resistant to nearly all quinolone antibiotics (red box). We consolidated this finding by MIC determination for Ciprofloxacin (>32 µg/ml), Gatifloxacin (>32 µg/ml), Moxifloxacin (>32 µg/ml), Norfloxacin (>256 µg/ml) and Ofloxacin (>32 µg/ml).
