Extended Data Fig. 1: Redundancy between DNA- and ICP0-triggered sensing of HSV-1 in BLaER1 monocytes.
From: Self-guarding of MORC3 enables virulence factor-triggered immunity
(a-c) BLaER1 monocytes were infected with HSV-1 at MOI = 1 for 24h or transfected with DNA for 3h. Gene-expression analysis is depicted as mean + SEM of three independent experiments. (d) Immunoblot of BLaER1 monocytes of indicated genotypes. (e) BLaER1 monocytes were infected with HSV-1 at MOI = 1 for 24h and IFNβ secretion was measured by ELISA. Data is depicted as mean + SEM of four independent experiments. (f) BLaER1 monocytes were infected with HSV-1 at MOI = 5. Gene-expression is depicted as mean + SEM of three independent experiments. * p < 0.05; ** p < 0.01; *** p < 0.001; ns = not significantly different than WT, tested by two-way ANOVA and Dunnett’s or Bonferroni’s post hoc test. See Source Data for exact p values
