Extended Data Fig. 2: Redundancy between DNA- and ICP0-triggered sensing of HSV-1 in THP1 and U937 cells.
From: Self-guarding of MORC3 enables virulence factor-triggered immunity
PMA-differentiated THP1 (a, c) or U937 (b) human myeloid-like cells were infected with HSV-1 at MOI = 1 or indicated MOI for 24h (a, b) or indicated timepoints (c) or transfected with 2ʹ−3ʹ-cGAMP for 4h. Gene-expression analysis is depicted as mean + SEM of three independent experiments. ND = not detected. * p < 0.05; ** p < 0.01; *** p < 0.001; ns = not significantly different than WT, tested by two-way ANOVA or Mixed-effects model and Bonferroni’s post hoc test. See Source Data for exact p values
