Extended Data Fig. 3: Unilateral inactivation of the direct pathway in VLS suppresses licking on both sides.
From: Striatal indirect pathway mediates exploration via collicular competition
a. Schematic showing strategy to inhibit striatal direct pathway. Mice expressing an inhibitory opsin GtACR1 in the direct pathway (R26-CAG-LNL-GtACR1-ts-FRed-Kv2.1 x Drd1a-Cre, see methods) was implanted with a tapered fiber in the right VLS. b. Example session during which a mouse underwent direct pathway inactivation similar to the experiment described in Fig.4b (see Methods). Trials are sorted by trial type similar to that described in Fig.1d. c. Percentage trial outcome for contra trials (top) and ipsi trials (bottom). Unilateral direct pathway inactivation lead to a decrease in correct rate and an increase in miss trial rate (P***<0.0005, two-tailed t-test; n = 5 mice, power = 2mW). d. Change in miss trials percentage for different power levels (0.2, 0.5 and 2mW).
