Fig. 3: Task input uncertainty engages the mouse MD.
From: Thalamic circuits for independent control of prefrontal signal and noise
a, Task schematic (see text). b, PL inactivation (blue) diminishes performance regardless of uncertainty level (n = 17 sessions, 5 mice; ***P < 7.72 × 10−4; chi-squared). c, Putative excitatory PL neurons showing responses during the cueing period, with the later neuron showing selectivity to the attentional choice (*P = 0.0157; Mann-Whitney U). d, Population decoding (top) and mutual information (bottom) show choice selectivity (n = 1,112 neurons from 7 mice). Both measures are modulated by uncertainty. e, MD inactivation (yellow) diminishes performance as a function of uncertainty (n = 56 sessions, 6 mice; ***P < 1.43 × 10−13; chi-squared). f, Example task-relevant MD neurons, one conflict-preferring and one conflict-non-preferring, both exhibiting little choice selectivity. g, Relative fraction of the MD neural functional types (n = 2,669 neurons from 7 mice). All statistical tests are two-tailed. Box plot parameters as in Fig. 1. Data are mean ± s.e.m. for b, e and mean ± 95% confidence interval (CI) for d.
