Extended Data Fig. 4: DDR1 dependent transcriptomic changes.
From: Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion
(a) Quantification of αCD31 IHC of WT and KO tumours transplanted from Rag1−/− to C57BL/6 hosts (n = 6 tumours; n.s., not significant). Data are presented as mean values +/− SEM. Two-tailed Student’s t-test (b) Comparison of non-synonymous tumour mutational burden between Ddr1-WT (n = 4 tumours) and KO tumours (n = 5 tumours, n.s., not significant). Data are presented as mean values +/− SEM. Two-tailed Student’s t-test (c) Venn diagram showing the numbers of DEGs in each Ddr1-KO-WT comparison and the identity overlaps between them. The pairwise overlap significance is indicated. The GO terms overrepresented (FDR-adjusted p < 0.05 relative to mouse genome background) in the overlapping sets are shown; the genes corresponding to each annotation are also indicated.
