Extended Data Fig. 6: Prioritized antigen parent genes are expressed during tissue development and downregulated in normal tissue after birth. | Nature

Extended Data Fig. 6: Prioritized antigen parent genes are expressed during tissue development and downregulated in normal tissue after birth.

From: RETRACTED ARTICLE: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs

Extended Data Fig. 6

a-f. Temporal transcriptomic analysis of prioritized neuroblastoma target antigens reveals high expression during development and downregulation prior to birth in the majority of target genes. Expression shown for each tissue from shown from 4 weeks post-conception to 58-63 years with birth marked by red arrows. PHOX2B (a), TH (b), IGFBPL1 (c), and CHRNA3 (d) exhibit developmentally restricted expression patterns. HMX1 (e) shows expression in testes post-birth. GFRA2 (f) expression in brain may make this target more amenable to targeting by antibody-based therapies that do not cross blood-brain barrier.

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