Extended Data Fig. 13: pMHC Cross-Reactivity Algorithm sCRAP Predicts MAGE-A3 toxicity through TITIN. | Nature

Extended Data Fig. 13: pMHC Cross-Reactivity Algorithm sCRAP Predicts MAGE-A3 toxicity through TITIN.

From: RETRACTED ARTICLE: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs

Extended Data Fig. 13

a. Table of top predicted cross-reactive peptides to MAGE-A3 peptide EVDPIGHLY reveals cross-reactivity with Titin peptide ESDPIVAQY ranks 4th out of 1,143,861 potential peptides presented on HLA-A*01:01. b. TITIN is highly expressed in GTEx RNA-sequencing of heart (n = 108) and muscle (n = 138) tissues.

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