Extended Data Fig. 4: Tumor antigens derived from parent genes are under control of neuroblastoma core regulatory circuit.
From: RETRACTED ARTICLE: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs
a. Illustration of core-regulatory circuit in which transcription factors bind to one another’s promoters, acting as feed-forward loop b. ChIP Seq data at prioritized neuroblastoma antigens parent gene loci are bound by each of the 7 core-regulatory circuit (CRC) proteins MYCN, ASCL1, GATA3, HAND2, PHOX2B, ISL1, and TBX2. All CRC binding sites are associated with a H3K27Ac super-enhancer element.
