Extended Data Fig. 5: Properties of neuroblastoma immunopeptidome.
From: RETRACTED ARTICLE: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs
a. Logo plots of peptides eluted from HLA-A2 and HLA-A24 show canonical binding motifs for both alleles64. b. Peptides detected by immunopeptidomics are enriched for highly expressed parent genes as compared to the entire cellular transcriptome. c. Gene ontology analysis of the parent genes of peptides of the neuroblastoma immunopeptidome compared to the cellular transcriptome. The most significantly enriched ontology groups are nucleic acid binding proteins (RNA binding protein ontology p = 1.22e−25 and nucleic acid binding ontology p = 9.47e−17; Fischer’s Exact test).
