Fig. 1: Identification of cross-neutralizing SARS-CoV-2 S protein-specific nAbs.
From: Hybrid immunity improves B cells and antibodies against SARS-CoV-2 variants
a, The graph shows supernatants that were tested for binding to the SARS-CoV-2 S protein antigen first detected in Wuhan, China. The threshold of positivity was set as two times the value of the blank (dotted line). The dark blue and dark red dots represent mAbs that bind to the S protein for vaccinees who were seronegative and seropositive, respectively. The light blue and light red dots represent mAbs that do not bind to the S protein for vaccinees who were seronegative and seropositive, respectively. OD, optical density. b, The bar graph shows the percentage of not-neutralizing antibodies (grey), nAbs from individuals who were seronegative (dark blue) and nAbs for individuals who were seropositive (dark red). The total number (n) of antibodies tested per individual is shown on the top of each bar in a, b. c, The graphs show the fold-change percentage of nAbs in individuals who were seronegative (left) and seropositive (right) against the Alpha, Beta and Gamma VoCs compared with the original SARS-CoV-2 virus detected in Wuhan. The heat maps show the overall percentage of the SARS-CoV-2 nAbs detected in Wuhan that are able to neutralize the tested VoCs.
