Extended Data Fig. 5: Off-target profiling of Z4446724338, Z1665845742 and Z4857158944. | Nature

Extended Data Fig. 5: Off-target profiling of Z4446724338, Z1665845742 and Z4857158944.

From: Structures of the σ2 receptor enable docking for bioactive ligand discovery

Extended Data Fig. 5

a–c, TANGO screens against a panel of 320 GPCRs for the indicated σ2 ligand. a, Z4446724338, b, Z1665845742, c, Z4857158944. d, GloSensor μOR-mediated cAMP inhibition (Gi activation) by DAMGO, Z4446724338, Z1665845742, and Z4857158944. e, f, Follow-up does-response curves for pain-related receptors that showed activation in a–c. e, Z4446724338 and Z1665845742 against 5HT1A. f, Z4857158944 against κOR. Data shown are means ± s.e.m

Source data.

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