Extended Data Fig. 10: Changes in cortical gene expression in response to LPS inoculation and treatment with CLU.

a. Number of DEGs (Wald test; P < 0.1) between Saline-treated mice (n = 4) and either LPS (n =8) or LPS+rCLU (n = 7) injected animals. b. Venn diagrams depicting the overlap of DEGs (shown in panel a) in whole cortex of mice inoculated with LPS or LPS+rCLU, relative to the Saline-injected controls. c – d. Boxplot representation of scaled expression levels of 200 differentially up- and down-regulated genes under LPS as opposed to Saline controls. Whiskers represent the first and fifth quartiles, box edges represent the second and fourth quartiles and the centre line represents the third quartile/median. Two-sided Wilcoxon rank-sum test. e – f. Representative GO enrichment categories of LPS significantly regulated genes. Lengths of bars represent negative ln-transformed P using two-sided Fisher’s exact test. Colours indicate gene-wise log2 fold-changes (log2(FC)) between (e) LPS and Saline treatment or (f) LPS+rCLU and LPS treatment. Numbers beside bars indicate DEGs induced by LPS in that GO category.