Extended Data Fig. 7: Functional features of transplanted microbiomes from mice exposed to smoke and at cessation.
From: Gut microbiota modulates weight gain in mice after discontinued smoke exposure
(a) Heatmaps describing the functional potential of metagenomic features (EC annotated) in shotgun metagenomics, corresponding to the conditions of Extended Data Fig. 6e. Features were grouped according to BRITE hierarchy; colored bar represents z score. (b–c) Weight change of GF C57BL/6 mice following FMT. Fecal donations were collected at day 24 of smoke exposure and cessation from abx-treated or untreated HFD-fed C57BL/6 mice (b) or NC (c); Day 28, unpaired two-sided t-test, mean ± s.e.m. (b) Recipients: HFD-fed C57BL/6 mice, SMK (n = 7) and SMK+abx (n = 6), mean ± s.e.m. (c) Recipients: NC-fed C57BL/6 mice, n = 6 per group, mean ± s.e.m. (d–e) Fecal calories of GF recipients after FMT from early smoke exposure (d, Non-SMK n = 5, SMK n = 6) or cessation (e, n = 5 mice per group); unpaired two-sided t-test, mean values. *P<0.05, **P<0.01, P values presented in Supplementary Table 1.
