Extended Data Fig. 3: Metabolic impacts of antibiotics treatment on SCWG.
From: Gut microbiota modulates weight gain in mice after discontinued smoke exposure
(a–c) Metabolic cage analysis during smoke exposure cessation over a period of 260h, n = 4 for all mice groups, HFD-fed mice. Locomotion (a, ‘cnts’ refers to light beam break count), food intake (b, total kcal), respiratory exchange ratio (c, RER); inset: AUC (baseline = 0, baseline of RER = 0.7). One-way ANOVA and Sidak correction, mean ± s.e.m. (d) Energy expenditure analysis during cessation over a period of 260h. Non-SMK and Non-SMK+abx (n = 8), SMK (n = 5), SMK+abx (n = 6). Inset: AUC (baseline= minimum score, 14.1), One-way ANOVA and Sidak correction, mean ± s.e.m. (e) Pearson correlation between fecal calories and weight gain rate, smoke exposure (circles) and cessation (triangles). SMK (smoke exposure period n = 8, cessation period n = 9, red), SMK+abx (smoke exposure period n = 9, cessation period n = 9, yellow). Lines represent linear regression slopes and intercepts. Grey background in graphs refers to the dark cycle. *P<0.05; **P<0.01; exact P values presented in Supplementary Table 1.
