Extended Data Fig. 3: Cryo-EM density map and atomic model comparisons.
From: Structure of pathological TDP-43 filaments from ALS with FTLD
a–c, Views of the cryo-EM density map of TDP-43 filaments from the frontal cortex of individual 1 and the corresponding atomic model showing representative densities for amino acid side chains (a), peptide group oxygen atoms (b) and ordered solvent molecules (red arrows) (c). d, Fourier shell correlation (FSC) curves for the refined atomic model against the cryo-EM density map (black); for the atomic model shaken and refined using the first half-map against the first half-map (magenta); and for the same atomic model against the second half-map (green). The FSC threshold of 0.5 is shown with a red dashed line.
