Extended Data Fig. 13: Spatial projection of single-cell whole-genome sequencing (scWGS) clusters.
From: Spatial genomics enables multi-modal study of clonal heterogeneity in tissues
a, Genomic copy number profiles for 2,274 single cells obtained using scWGS, with cluster annotations colored. b, Top left: projection of scWGS clusters onto slide-DNA-seq. All other: three genomic regions of differential CNA profiles between the three projected clusters, shown are spatial heatmaps of signed p-value differences from the average profile (two-sided permutation test, not adjusted for multiple comparisons). c, Normalized copy number profiles for the three scWGS clusters, and the corresponding spatial clusters. Vertical lines denote variable regions from b. Single-cell cluster 2 (blue) shows complex CNA patterns that obscure cluster ploidy, nevertheless, copy number values are normalized to 2 for easy comparison to other clusters.
