Extended Data Fig. 14: Tumor morphology of primary human colon cancer sample.
From: Spatial genomics enables multi-modal study of clonal heterogeneity in tissues
a, H&E stain of normal colon (left) and colon tumor (right) tissue from the same patient. Scale bars, 200 μm. b, Serial sections processed for H&E stain (left), slide-DNA-seq (center), and slide-RNA-seq (right). Scale bars, 500 μm. Yellow and black boxes indicate magnified areas in c, d, respectively. c, Magnified views of H&E stain, slide-DNA-seq and slide-RNA-seq reconstructions show concordant spatial tissue architecture across three modalities; scale bar, 200 μm. d, Magnified view of H&E stain of three regions that are assigned low, medium, and high tumor density by slide-RNA-seq transcriptomic analysis (b, right). Arrows indicate regions of high tumor density identified through H&E stain. Scale bar, 100 μm.
