Extended Data Fig. 3: Comparison of all identified Extended and Core EXOmotifs (a) and CELLmotifs (b) among the five different cell types.

a) Fold enrichment (left half) and abundance (right half, as percentage of sEV-enriched miRNAs) containing the sEV-associated miRNA motifs. The first column indicates the cell type where these motifs were originally identified (see Main Fig. 2a) and here shown in its predominant form in the second column (Extended motifs) and fifth column (Core motifs). The fold enrichment is shown in a red (high sEV enrichment)-white (neutral)-blue (cell enrichment) color gradient for indicated cell types displayed below. The abundance is shown in a red (high)-white (low) color gradient. The rectangles highlight the enrichment and presence of the motifs in the cell types where they were originally identified. b) Fold enrichment (left half) and abundance (right half, as percentage of cell-enriched miRNAs) containing the Cell-associated miRNA motifs. As in a), the first column indicates the cell type where these motifs were originally identified (see Main Fig. 2b) and here shown in its predominant form in the second column (Extended motifs) and fifth column (Core motifs). The fold enrichment is shown in a blue (high cell enrichment)-white (neutral)-blue (red sEV enrichment) color gradient for indicated cell types displayed below. The abundance is shown in a blue (high)-white (low) color gradient. The rectangles highlight the enrichment and presence of the motifs in the cell types where they were originally identified.