Extended Data Fig. 3: Transcriptome analysis of IGRP-specific CD8 T cells from pancreatic lymph node and pancreas.
From: An autoimmune stem-like CD8 T cell population drives type 1 diabetes
a, MA plot of RNA-seq of pLN TCF1hi and pLN TCF1lo IGRP-specific CD8 T cells. Significantly differentially expressed genes are colored in light or dark blue and labeled with *. Selected genes are highlighted. b, Gene ontology (GO) term analysis of differentially expressed genes in pLN RNA-seq data set. GeneRatio>20/X. P-adj<0.01. Statistical testing conducted via hypergeometric test with Benjamini-Hochberg correction. c, GSEA of pLN TCF1hi and pLN TCF1lo cells including Hallmark and KEGG gene sets. d, Over-representation of KEGG and Hallmark pathways and GO terms in groups 1 and 4. P-adj<0.05.
