Table 1 Statistical analysis of the rhesus macaque challenge study

From: Long-acting capsid inhibitor protects macaques from repeat SHIV challenges

 

Proportion of animals protected

Median weeks to viraemia (95% CI)

Hazard ratio (95% CI)/per-exposure risk reduction

P value

Vehicle control

0/8

7.5 (2, 14)

1

–

GS-CA1, 150 mg kg−1

2/8

16 (11, –)

0.127 (0.03–0.51)/87%

0.0038

GS-CA1, 300 mg kg−1

5/8

Not reached (17, –)

0.033 (0.0059–0.188)/97%

0.0001

  1. Proportion of animals protected, median time (in weeks) to viraemia, estimated hazard ratios from the Cox proportional hazard model and corresponding P values comparing animals receiving vehicle control and GS-CA1 are shown. CI, confidence interval.
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