Extended Data Fig. 3: Frequency and phenotype of antigen-specific CD8⁺ T cells relative to disease severity.

a, Frequency of CoV2-Dex⁺ CD8⁺ T cells in healthy controls and patients with mild and severe disease during acute COVID-19 six months and one year after infection (n = 10 healthy; acute: n = 21 mild, n = 15 severe; six months: n = 18 mild, n = 16 severe; one year: n = 19 mild, n = 10 severe). b–d, Frequency of Ki-67⁺, HLA-DR⁺, granzyme B⁺, CX3CR1⁺ and CD127⁺ in CoV-2Dex^– and CoV2-Dex⁺ cells in patients with mild versus severe disease (b) during acute infection, (c) six months and (d) one year after infection (acute: n = 16 mild, n = 12 severe; six months: n = 11 mild, n = 16 severe; one year: n = 19 mild, n = 10 severe). P-values were calculated with a Mann-Whitney-Wilcoxon test and adjusted for multiple comparisons using the Holm method. All tests were performed two-sided.