Extended Data Fig. 5: Characteristics of antigen-specific CD8+ T cells six months after infection.
From: Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infection
a, UMAP plot of transcriptomes from CD8+ T cells of healthy individuals (gray), COVID-19 patients in acute infection (red), and six months after infection (blue). b, Cluster contribution to total CD8+ T cells of healthy subjects, acute infection, and six months after infection. c, UMAP plots of marker expression for up to 2,000 CD8+ T cells from each sample collected six months after infection analyzed by spectral flow cytometry. Regions with high expression of specific markers appear red. Overlay of CoV2-Dex+ cells (red) and total CD8+ T cells (gray) is shown on the upper left. d, Percentages of CoV2-Dex+ cells contributing to indicated clusters during acute infection or six months after infection. Percentages are calculated on total cells per cluster per timepoint. e, Expression of selected genes (italicized), as well as CCR7 and CD45RA proteins determined by TotalseqTM, for CoV2-Dex+ cells detected in the acute versus recovery phase. P-values were calculated using a Mann-Whitney-Wilcoxon test and a Bonferroni correction was applied for multiple comparisons.
