Extended Data Fig. 8: Bodyweight and transmission in hACE2-K18Tg mice.
From: Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta
hACE2-K18Tg mice inoculated with a mixture of wt-S614G and Alpha, or wt-S614G and wt-SAlpha. (a) Relative body weight of individual donor mice (n = 4 mice/group; left panel), and contact mice (n = 4 mice/group; right panel). (b) Pie chart colors illustrate the ratio of wt-S614G (orange) with Alpha (dark blue), or with wt-SAlpha (light blue) in corresponding experiments in lung homogenates of contact mice at 7 dpc (i.e., 8 dpi of donor mice). Pie chart sizes are proportional to the total viral genome copies reported below. Grey pies indicate values below the LOD (<103 viral genome copies per sample).
