Fig. 3: Replication and transmission of SARS-CoV-2 Alpha and wt-S614G in ferrets.
From: Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta
Six donor ferrets were each inoculated with a TCID50 of 105.9, determined by back titration and comprising a mixture of wt-S614G and Alpha at a 1:1.2 ratio, determined by RT–qPCR. Donor, contact 1 and contact 2 ferrets were co-housed sequentially as shown in Extended Data Fig. 2b. Pie charts show the ratio of variants detected in nasal washes at the indicated dpi. Pie chart sizes are proportional to the total number of viral genome copies per ml, as shown above or below each chart. Grey pies indicate values below the LOD. Viral genome copies were below the LOD at 18 and 20 dpi (not shown). Ferret silhouettes are coloured to indicate the dominant SARS-CoV-2 variant (>66%) detected in the last positive sample from each ferret.
