Extended Data Fig. 9: GSDMA proteins in different species.
From: Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
Multiple sequences alignment of human (h), chimpanzee (cp), monkey (mk), rat (r), dog (dg) GSDMA and mouse Gsdma1, Gsdma2 and Gsdma3 was performed using the ClustalW2 algorithm and plotted by ESPript program. Identical residues are highlighted by red background, and similar residues are indicated in red. Ile 245 and Gln246 (*) in human GSDMA are highly conserved in chimpanzee, monkey, rat, dog GSDMA as well as mouse Gsdma1.
