Extended Data Fig. 3: Omicron neutralization IC50 fold-change distribution of 247 neutralizing antibodies of diverse epitopes. | Nature

Extended Data Fig. 3: Omicron neutralization IC50 fold-change distribution of 247 neutralizing antibodies of diverse epitopes.

From: Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Extended Data Fig. 3

Fold-change of IC50 (VSV pseudovirus neutralization) compared to D614G by Beta and Omicron (BA.1) are shown for all 247 neutralizing antibodies tested. The effect of each RBD mutation of Omicron on antibody binding is inferred from yeast display mutation screening. Each antibody’s binding to Omicron RBD was validated through ELISA. All neutralization and ELISA assays were conducted in biological duplicates.

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